blog-articals

Male obesity and infertility

                           

Obesity is considered a global health problem affecting more than a third of the population.  Obesity is known to disrupt male fertility and the reproduction potential, particularly through alteration in the hypothalamic‐pituitary‐gonadal axis.

Affects of obesity

  1. Altered hormone profile: Testosterone and gonadotropins levels were low and estrogen levels were found to be high in obese men.
  2. Sperm concentration, motility and morphology: obesity has a negative impact on semen parameters (count, motility and morphology).
  3. Serum leptin level: Increased levels of leptin might suppress the testosterone secretion by inhibiting the Leydig cell function.
  4. Sleep apnea:  Characterized by disturbed sleep
  5. Erectile dysfunction: High blood pressure caused by obesity can affect the way blood flows to the penis, sometimes making it difficult to achieve or maintain an erection.
  6. Obesity inhibits chromatin condensation, DNA fragmentation, increases apoptosis and epigenetic changes that can be transferred to the offspring.
  7. Raised temperature: Increased testicular heat is associated with lower sperm count and quality. The insulation of excess body fat may raise the temperature in the scrotum, causing damage to the sperm.

Management

       Pharmacotherapy

  • Appetite suppressors
  • Aromatase inhibitors
  • Clomiphene citrate

Diet and exercise

  • Lifestyle modifications that include caloric restriction
  • Increased physical activity 

Surgery

  • Bariatric Surgery: Azoospermic men undergoing gastric bypass demonstrate increased serum testosterone and sperm count after bariatric surgery.
  • Scrotal lipectomy

You May Also Like