Pre mature ovarian failure


It is also called primary ovarian insufficiency. The ovaries stop functioning normally and this means that they stop ovulating or releasing egg cells and also stop producing hormones mainly estrogen and progesterone this happens before a women 40 years old. It’s considering a primary problem because problem is with the ovaries themselves rather than the glands or the hormones that act on the ovaries. Premature depletion of ovarian follicles/arrested folliculogenisis before the age of 40 years occurs in pre mature ovarian failure.


  1. Chromosomal abnormality
  2. Pelvic surgery
  3. Chemotherapy and radiation therapy
  4. Fragile X syndrome
  5. Follicle-stimulating hormone receptor mutations
  6. Trisomy X (47XXX 
  7.  Ataxia telangiectasia
  8.  Mumps oophoritis


  1. Hot flashes
  2. Anxiety depression
  3. Night sweats
  4. Trouble sleeping
  5. Vaginal dryness
  6. Mood swings
  7. Osteoporosis


  • Low levels of gonadal hormones and
  • High gonadotropins (LH and FSH)
  • Ultrasound frequently reveals small ovaries without evidence of growing follicles.
  • Menstrual irregularity for at least 3 consecutive months.


  • Hormonal therapy: The goals of hormonal therapy extend beyond simply symptom relief to levels that support bone, cardiovascular (CV), and sexual health.
  • In girls with absent or incomplete breast development, estrogen therapy should be initiated and increased slowly before administration of graduated progesterone dosages until breast development is complete.
  • Calcium and vitamin supplements.

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