Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) is a modification of the traditional Intracytoplasmic Sperm Injection (ICSI) technique used in in vitro fertilization (IVF). IMSI involves the selection of sperm using advanced microscopy to identify morphologically normal sperm with the least amount of abnormalities.
ICSI has revolutionized the treatment of male infertility by enabling fertilization of oocytes using a single sperm cell injected directly into the oocyte. However, this technique does not take into account the morphology of the sperm being used. Sperm selection using conventional ICSI is limited to identifying major morphological defects, while minor defects such as vacuoles in the sperm head cannot be visualized.
IMSI uses an inverted light microscope with high power Nomarski optics enhanced by digital imaging to achieve a magnification of up to 6600x. This allows for the selection of the most morphologically normal spermatozoa just prior to performing the ICSI. The sperm are subjected to MOSMP criteria (motile sperm organelle morphology examination) which involves analyzing the sperm for structural and functional integrity, thereby allowing for the selection and injection of normal sperm cells that are free of vacuoles.
The IMSI technique has been found to improve the outcomes of ICSI in patients with severe male factor infertility. It allows for the selection of the best sperm cell, which increases the chances of successful fertilization and ultimately improves the chances of a successful pregnancy. Aashakiran IVF, like other IVF clinics, offers IMSI as an option for couples who have been experiencing male factor infertility. The use of IMSI is one of the many ways Aashakiran IVF is committed to providing the best possible care to couples struggling with infertility.